The fission yeast Rpb4 subunit of RNA polymerase II plays a specialized role in cell separation.

Both the lists of genes being upregulated and downregulated after rpb4 down-regulation showed highly significant overlaps with lists of genes upregulated or downregulated, respectively, in sep10, sep15, mcs6 and pmh1 mutants ( P ∼ 1 × 10 −16 to 1 × 10 −47 ) (Lee et al. 2005 ), whose genes encode different proteins involved in transcriptional regulation (see Discussion ).

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