Discussion Previous studies involving comparative genomics and explorative genome-wide multilocus analysis conclusively showed that the present MTBC strains appear as a genetically homogeneous clonal pool, since they display a highly significant linkage disequilibrium and an exceptionally low rate of silent nucleotide substitutions [ 4 , 7 , 33 , 35 - 37 ].
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Insights into the evolutionary history of tubercle bacilli as disclosed by genetic rearrangements within a PE_PGRS duplicated gene pair.
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