Lack of mucosal immune reconstitution during prolonged treatment of acute and early HIV-1 infection.

When assessed as a group, the difference between PBMC and MMC CD4 + T cell percentage was highly significant after 1 y (57.9% ± 11.9% CD4 + PBMCs versus 34.6% ± 4.2% CD4 + MMCs; p < 0.001), 2 y (54.4% ± 10.9% CD4 + PBMCs versus 30.8% ± 9.8% CD4 + MMCs; p < 0.001), and 3 y (67.3% ± 9.8% CD4 + PBMCs versus 41.3% ± 4.9% CD4 + MMCs; p = 0.02) of suppressive antiviral therapy ( Figure 1 D).

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