In summary, while highly significant and expected effects of high versus low were measured for dfe penetrance, the high and low penetrance dfe lines did not differ in any of eight laboratory tests of fitness, countering widespread suggestions that Hsp90 buffered phenotypes in Drosophila necessarily suffer large, “unconditionally deleterious” fitness effect, the most frequent challenge to the ‘Hsp90 capacitor hypothesis’ [2] , [11] – [14] .
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