A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation.

PLoS One · 2006 · PMC1762433 · PMID 17205132

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highly significantno p-value reported

Through a series of stringent searches, we identified a highly significant (within 0.041 percentile) D-domain in amino acids 179-193 ( Fig. 2A ), suggesting that the Ras/Raf/MEK/ERK MAPK signaling cascade might be responsible for cyclin D1 phosphorylation.

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