ICI 182,780 has agonistic effects and synergizes with estradiol-17 beta in fish liver, but not in testis.

Reprod Biol Endocrinol · 2006 · PMC1769500 · PMID 17192186

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highly significantno p-value reported

However, ICI-pretreatment at the two doses tested strongly potentiated the effect of E 2 on calcium causing a highly significant ~2 fold increase within two days and a further ~1.5 fold increase in the next 6 days with the highest ICI dose (I 35 E3d).

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