highly significantp = 3.10 -3
Overall, the differences in numbers of up- versus down-regulated transcripts in responders versus non-responders were highly significant, whether considering only the number of transcripts with a significant difference at baseline versus 3 months ( n = 8, p = 3.10 -3 , Fisher's exact test) or considering the complete set of transcripts and associated trends ( n = 20, p < 10 -4 by Fisher's exact test, or p = 0.007 by analysis of variance).