highly significantp < 0.0001
We found a highly significant increase in synaptic abnormalities in oocytes from BPA-exposed females (16.0% versus 52.0% of cells in placebo and BPA, respectively; χ 2 = 134.8; p < 0.0001; Figure 1 A), largely attributable to increases in two categories of abnormality: “incomplete synapsis,” in which a single chromosome pair remained unsynapsed in an otherwise normal pachytene cell (0.5% in placebo versus 11.0% in BPA; Figure 1 C), and cells with end-to-end associations between nonhomologous SCs (7.7% in placebo versus 25.6% in BPA; Figure 1 D).