Reduction of nosocomial pneumonia after major burns by trace element supplementation: aggregation of two randomised trials.

There are minor differences between the designs of the two studies we merged: (a) doses of and length of administration of supplements of selenium, of copper, and of zinc were higher in the second trial, (b) the primary metabolic and nutritional endpoints differed slightly (Table 1 ), (c) the studies were consecutive in time, which might have been associated with modest changes in general therapeutic procedures, and (d) despite the highly significant results, the number of patients was low.

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