Tagging single nucleotide polymorphisms in the BRIP1 gene and susceptibility to breast and ovarian cancer.

Despite the large sample size, neither association is highly significant (P = 0.047 and 0.02 respectively) and the P-values have not been adjusted for multiple hypothesis testing.

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However, these associations were only of borderline significance, and so need to be interpreted with some caution.

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There was also evidence for a borderline significant effect for the rare allele of rs4988344, which was associated with an increased risk in a dose-dependant manner (OR = 1.15 [95%CI 1.02–1.30], P-trend = 0.02), compared with common homozygotes.

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The samples were split into two sets in order to save DNA and reduce genotyping costs: the first set (n = 2270 cases and 2280 controls) was genotyped for all SNPs and the second set (n = 2203 cases and 2280 controls) were then tested for those SNPs that showed marginally significant associations in set 1 (P-heterogeneity or P-trend<0.1).

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