Recharacterization of ancient DNA miscoding lesions: insights in the era of sequencing-by-synthesis.

Nucleic Acids Res · 2007 · PMC1802572 · PMID 16920744

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highly significantno p-value reported

Cytosine to uracil deaminations clearly are important—the resultant manifestation of C→T transitions are observed here at a highly significant rate (in comparison to the enzyme misincorporation rates), and cytosine to uracil deamination has been experimentally identified through previous UNG treatment assays of purified aDNA ( 4 , 8 , 9 ).

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