The relationship between anti-HPV-16 IgG seropositivity and cancer of the cervix, anogenital organs, oral cavity and pharynx, oesophagus and prostate in a black South African population.

Consistent with a recent multi-centre study [ 3 ], we observed a weak association between anti-HPV 16 IgG antibody levels and cancer of the oral cavity and pharynx, but the test for trend ranged from borderline significance in the initial model, adjusted for age and sex (p = 0.05) to non-significant (p = 0.13) when all the important confounding variables were retained, suggesting that some confounding by lifestyle may be important.

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Cancers of the oral cavity and pharynx showed a borderline significant association in the unadjusted model (p = 0.05) but after adjustment for confounding the trend in relation to Ab levels was positive but not statistically significant (OR for medium Ab = 1.1, and high Ab = 1.5 p = 0.13).

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An increasing trend in the risk of developing cancer of the cervix was found in relation to increasing anti-HPV-16 IgG levels; those with medium and high levels having adjusted odds ratios (OR) of 1.63 and 2.48 respectively (p trend <0.0001).

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