Once processed as above, the data can be divided into five different significance levels: significance level +2 = z ratio >1.5 and significant replication ( P < 0.05); significance level +1 = z ratio >1.5 and no significant replication ( P > 0.05); significance level 0 = neither condition is true; significance level -1 = same as +1 but wild type > knockout; and, finally, significance level -2 = same as +2 but wild type > knockout Genes that attain significance levels of +2 and -2 are highly significant and are considered differentially expressed between experimental groups.
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Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain.
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