An expression signature of syndecan-1 (CD138), E-cadherin and c-met is associated with factors of angiogenesis and lymphangiogenesis in ductal breast carcinoma in situ.

A highly significant correlation of c-met expression with ET A R and ET B R was found; 92.6% of c-met positive DCIS versus 56.7% of c-met negative DCIS stained positive for ET A R ( P < 0.001), and 57.4% of c-met positive tumours versus 23.4% of c-met negative tumours stained positive for ET B R ( P < 0.001).

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