Barely Significant
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E2F8 is a nonreceptor activator of heterotrimeric G proteins.

J Mol Signal · 2007 · PMC1852105 · PMID 17394670

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may be significantno p-value reported
It may be significant that the newer E2Fs are structurally dissimilar to the previously described and well-characterized E2F1–6; unlike these, both E2F8 and E2F7 lack a DP dimerization domain and can bind to DNA efficiently in the absence of DP [ 22 - 24 , 36 - 38 ].

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