Regulation of N-WASP and the Arp2/3 complex by Abp1 controls neuronal morphology.

This ability of the Abp1 C-terminus to activate actin filament formation mediated by N-WASP in vivo is clearly reflected in the highly significant (p<0.01) increase of transfected cells that display filamentous actin at the surface of N-WASP/Abp1-C-terminus-decorated mitochondria ( Figure 6O ; 90±6% in Mito-GFP-N-WASP/Abp1 flex/SH3 cotransfected cells versus 73±2% in cells transfected with Mito-GFP-N-WASP alone).

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