Common variants in the ATM, BRCA1, BRCA2, CHEK2 and TP53 cancer susceptibility genes are unlikely to increase breast cancer risk.

Breast Cancer Res · 2007 · PMC1868915 · PMID 17428325

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marginally significantno p-value reported

The samples have been split into two sets in order to save DNA and reduce genotyping costs: the first set ( n = 2,271 cases and 2,280 controls) is genotyped for all SNPs and the second set ( n = 2,203 cases and 2,280 controls) is then tested for those SNPs that show marginally significant associations in set 1 (P-heterogeneity or P-trend <0.1).

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