Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily.

Accordingly, we used a microarray approach to examine the family of FGFs and their receptors, comparing the effects of two different organophosphates, chlorpyrifos and diazinon, to emphasize points of similarity and difference: if the developmental neurotoxicity of the organophosphates involves neurotrophic mechanisms unrelated to the inhibition of cholinesterase, then there may be significant disparities in their impact on neurotrophic factors.

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