a nonsignificant trendp = 0.07
A nonsignificant trend ( p = 0.07) was observed between accumulation of motif-associated polymorphisms in protease/RT (but not other proteins) and lower median CD4 + cell counts, while no significant association was observed between clinical parameters and the presence of biologically unsupported associations, consistent with a stepwise enrichment for false-positives among associations in these categories.