Cloning and characterization of an adenoviral vector for highly efficient and doxycycline-suppressible expression of bioactive human single-chain interleukin 12 in colon cancer.

Both IL-12 preparations resulted in highly significant activation of CD4+ and CD8+ cells (p < 0.0001 each) with no significant difference in between heterodimeric IL-12 and single-chain IL-12 (CD4+: p = 0.124, CD8+: p = 0.092) concluding equal bioactivity for both cytokines (figure 5B ).

also in 132,142 other papers