Comparison of C. elegans and C. briggsae genome sequences reveals extensive conservation of chromosome organization and synteny.

Using a simple two-hit model to account for the difference in chromosome number, and the ratio of break points attributable to translocations and intrachromosomal rearrangements in mammals to estimate the expected number of translocations in nematodes, the failure to observe any validated translocation events in nematodes is highly significant ( p < 0.0001).

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