Endonuclease-independent insertion provides an alternative pathway for L1 retrotransposition in the human genome.

Nucleic Acids Res · 2007 · PMC1920257 · PMID 17517773

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highly significantno p-value reported

Statistical comparisons of the amounts of deviation from the consensus revealed a highly significant difference between the cleavage site preferences of NCLI loci versus a larger set of 282 recent TPRT-mediated L1 insertions ( 22 ) (unpaired t -test assuming unequal variances; P < 0.0001) ( 37 ), further bolstering our conclusion that breaks in the target DNA at NCLI loci were not products of L1-EN cleavage.

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