A specific box switches the cell fate determining activity of XOTX2 and XOTX5b in the Xenopus retina.

Failure to address all transfected cells to a single and specific fate may be due to differences in their time of cell cycle exit, which may underlie the diverse competence of progenitors; it may be significant, in this respect, that the effect of Xotx5b in enhancing photoreceptor fate is potentiated when co-transfected with X-gadd45γ , which promotes cell cycle exit [ 47 ].

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