TP53 mutation status and gene expression profiles are powerful prognostic markers of breast cancer.

Breast Cancer Res · 2007 · PMC1929092 · PMID 17504517

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0670

boldest claim

The sentences

highly significantp < 0.001actually significant

The histological type and grade, as well as ER and TP53 mutation status all showed a highly significant skewed distribution between the gene expression groups ( p < 0.001; Figure 4 ).

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close to being significantP = 0.067so close (0.05 < p ≤ 0.1)

In univariate Cox regression analysis two of the gene lists were significant in predicting breast cancer survival (15/21 genes: relative risk (RR) 3.70, 95%CI 1.64 to 8.34, P = 0.0007; 63/76 genes: RR 2.24, 95%CI 1.09–4.61, P = 0.028), while the third was close to being significant despite the limited number of overlapping genes (26/70 genes: RR 1.99, 95%CI 0.93 to 4.26, P = 0.067).

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