Divergent evolution of human p53 binding sites: cell cycle versus apoptosis.

Secondly, among those p53 REs exhibiting high conservation, mutations or polymorphisms that alter such sequences may be significant [ 35 ].

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The differences in positional sequence diversity between the two p53 RE subgroups were all highly significant (two-tailed paired t-test assuming unequal variances: dog = 1.4e−13, mouse = 4.3e−12, rabbit = 2.0e−17, and rat = 2.0e−15).

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