Pooling all three-brain regions together demonstrated a highly significant correlation between Sp1 and both genes in normal subjects, while in schizophrenic patients there was no correlation with NADUFV2 , and Sp1 correlation with NADUFV1 was significantly reduced.
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Sp1 expression is disrupted in schizophrenia; a possible mechanism for the abnormal expression of mitochondrial complex I genes, NDUFV1 and NDUFV2.
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