A highly significant association was found between the clinical assessment of response after 6 months, and changes in tumour marker concentration (above 6 ng ml-') during all three periods of treatment (Table II: pre-treatment vs 1-2 months, x2 = 15, 1 d.f.; vs 3-4 months, x2 = 33.8, 1 d.f.; vs 5 -7 months, X2 = 28.16, 1 d.f.).
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An objective biochemical assessment of therapeutic response in metastatic breast cancer: a study with external review of clinical data.
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