A bispecific monoclonal antibody against methotrexate and a human tumour associated antigen augments cytotoxicity of methotrexate-carrier conjugate.

Cytotoxicity against 788T cells which express high levels of gp72 is highly significant (P <0.001 at all antibody concentrations), but T24 and C170 with low gp72 expression are unaffected. y n ar T A at A x- d T as as at ly 4, e iW at ie es iC re ee 80 - 60 - C.2 x~ 40 ** 0 0 0 - 20 - . . . . 20 I 0.1 1 10 100 1000 100000 MTX/MTX-HSA concn (ng ml -' MTX) Figure 4 Comparative titrations of MTX and MTX-HSA against osteogenic sarcoma 788T cells with or without bispecific antibody (10,tgmlh').

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