Amplification and protein over-expression of the neu/HER-2/c-erbB-2 protooncogene in human breast carcinomas: relationship to loss of gene sequences on chromosome 17, family history and prognosis.

This differ- ence is highly significant (x2 = 7.05, P = 0.016).

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No significant differences between amplified and non-amplified tumours were observed with regard to node status, clinical stage, tumour size or menopausal status, although correlations of borderline significance were found between node status, clinical stage and high degree of gene amplification.

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No significant differences were found for any compari- sons except borderline significant associations between node positive tumours and loss of 17p, and between patients with postmenopausal disease and loss of 17q.

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