Has chemotherapy proved itself in head and neck cancer?

TOBIAS was clearly better in the combination group (75% vs 49%). No difficulties with surgical resection were encountered, in- deed several patients underwent planned operations, and the combination of chemo-radiotherapy with planned surgery seemed particularly successful, with no reported local recur- rences in this subgroup. Several smaller uncontrolled studies have been reported, with an increasing trend towards combination chemotherapy often involving cisplatin and 5-fluorouracil following the demonstration of high activity of this combination (Al Sarraf et al., 1980; Kish et al., 1985; Taylor et al., 1985).

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