The pharmacokinetics of 5-fluorouracil administered by arterial infusion in advanced colorectal hepatic metastases.

There were highly significant differences between the intravenous and intra-arterial combination infusion parameters (Cmax, P<0.001; AUC, P<0.003; clearance, P<0.01), and Table I Pharmacokinetic studies of intra-venous and intra-hepatic arterial infusion of 5FU (30 mg kg- ' body weight over 2 h) with and without angiotensin II and albumin microspheres in patients with advanced colorectal hepatic metastases n C.

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Intra-arterial treatment with microspheres and angiotensin II produced AUC and clearance values which were intermediate between intra-arterial infusion alone and intravenous infusions. In the 24 h infusions, there was an increasing trend in drug clearance, and a falling trend in AUC with intravenous SFU, intra-hepatic 5FU, and intra-hepatic arterial drug with angiotensin II and microspheres respectively (Table II).

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