4-hydroxyandrostenedione--further clinical and extended endocrine observations.

After 8 and 16 weeks of fortnightly therapy, levels had risen to 105% and 89% for oestradiol and 110% and 86% for oestrone respectively. Cortisol levels fell, from a pretreatment level of 490nmoll1' to a mean of 334nmoll1' after 2 weeks, then rising to 370 nmol l-' after 8 weeks (Figure 3), the fall between weeks 0 and 2 being highly significant (P = 0.0012).

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