was, thus, suggested that chemotherapy might influence tumour growth by sup- pression of ovarian endocrine function, besides exerting a direct cytotoxic effect. Similarly, in the ECOG trial (Tormey et al., 1990) patients developing DIA during adjuvant therapy with CMF, CMFP or CMFPT had a highly significant better survival.
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Prognostic role of amenorrhea induced by adjuvant chemotherapy in premenopausal patients with early breast cancer.
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