Influence of reducing luxury calories in the treatment of experimental mammary carcinoma.

The correlation of tumour volume, measured at the end of study, and of tumour weight determined at necropsy was highly significant (P <0.01) with r = 0.86 for the equation of linear regression y = 0.95x-0.06.

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.5) an = Number of animals at termination of study, bND = normal-Diet, percentage of total energy: 45%, 35%, 25%, 'mean (standard deviation), dp = 0.01, significant difference between the tumour volumes of all high caloric groups versus the respective low caloric groups, cp = 0.04, fP = 0.06, marginally significant difference between the tumour numbers of all high caloric groups versus the respective low caloric groups, gtime of dietary change, hweeks after dietary change, 'termination of experiment.

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How 'mild dietary restrictions' in the form of ad libitum feeding followed by alternate fasting can be adapted to the human situation remains open. Surgical removal of tumours at a size of 1 cm3 followed by reduction of luxury calories led to an almost significant inhibition of new tumour growth but not to a decreased recurrence rate of tumours in our study.

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