p53 protein expression in human breast carcinoma: relationship to expression of epidermal growth factor receptor, c-erbB-2 protein overexpression, and oestrogen receptor.

= 1), P = 0.032 (see Table III). Clinicopathological associations and patient survival There was a trend towards significance of p53 expression and increased regional tumour recurrence in 143 patients on whom recurrence data was available x2 = 3.20 (d.f. = 1), Table II Tumour p53, EGFR and c-erbB-2 immunoreactivity and tumour grade Tumour p53 EGFR c-erbB-2 Grade POS/NEG POS/NEG POS/NEG 1 3/18 5/16 3/18 2 15/32 12/35 20/27 3 43/35 31/47 35/43 P<0.001 (S) P = 0.16 (NS) P = 0.035 (S)a a(S) Statistically significant; (NS) Not statistically significant. 58S 586 D.N.

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