Vascular function and tissue injury in murine skin following hyperthermia and photodynamic therapy, alone and in combination.

Highly significant changes in relative vessel number in the treated group occurred between 7 and 21 days (P721 <0.001), with further insignificant changes by day 28 (P21-28 = 0.250). -U 0 2 4 6 8 1010 20 Time after treatment (days) 30I 40 50 30 40 50 Figure 2 Exponential half-time of clearance from the tail of '33Xe, as a function of time after hyperthermia at 43C.

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Only with the restoration toward the normal relationships of the different-sized vessels by 21 or 28 days, was the enhancement of injury abrogated. It may be significant that, using the mouse foot model and a 'tolerance' dose of hyperthermia (44?C for 60 min), Haveman et al.

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