Barely Significant
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Stability of oestrogen receptor status in sequential biopsies from patients with breast cancer.

Br J Cancer · 1987 · PMC2002150 · PMID 3663465

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an apparent trendno p-value reported
There is an apparent trend for + / + tumours to 'lose' receptor with time.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.