The earliest CN F2 tumnour was found at 16 months and the earliest NC F2 tumour at 12 months. Comparing F1 and F2, the NC F2 incidence was significantly lower than the NC F1,14 but the difference between CN F1 and F2 was barely significant.15 The mean tumour ages for the 2 generations were in agreement except for the CN males.'6 As a larger proportion of CN F2 males died at an earlier age than did those of F1, there was a greater opportunity for the discovery of early tumours in CN F2.
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The effect of methylcholanthrene on the incidence of lung tumours in two inbred strains of mice and their reciprocal hybrids.
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