This might be significant, firstly because assessment of chemotherapeutic agents is sometimes based on the results obtained merely from the exponential growth in murine leukaemia system such as the effect of BCNU on L1210 leukaemia (Skipper et al., 1964); secondly because of the enormous capacity of the liver for proliferation of leukaemic cells in the advanced stage, it may be difficult to eradicate malignant cells completely from infiltrated organs with therapeutic drugs.
1
—
—