Effects of time and duration of progesterone administration on mammary tumours induced by 7,12-dimethylbenz(a)anthracene in Sprague-Dawley rats.

This difference was based on rela- tively small numbers of classifiable neo- plasms (32 in Groups 2-4 and 20 in Group 1), but again it appeared to be due to a relative excess of regressing growths in Group 1. No other significant effects on TGB were found (Table IV). A highly significant difference was observed between the number of tumours which reached a measurable size (1cm or more in longest diameter) of all those that developed in the control group (1) compared with those arising in the 8 progesterone-treated groups (P < 0.01) (Table III and IV).

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