This is presumably due to prolonged exposure of local lymphocytes to relatively high concentrations of soluble antigen, causing a specific immunological paralysis (Alex- ander, 1970; Baldwin, Price and Robins, 1 972). WNThatever the cause of the local lym- phocyte anergy, the phenomenon is pre- sumably highly significant biologically and may be the explanation of tumour spread and regional metastasis despite local abundance of lymphocytes.
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