Chromosome 11 allele imbalance and clinicopathological correlates in ovarian tumours.

A highly significant association between allele imbalance on 17p and 17q in this material has been observed previously (Fisher's exact test, P = 0.0007; data not presented).

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00 0 E d 80 60 40 20 'a L- U) 51) '- E 0 Time (years) Figure 5 Kaplan - Meier survival curve with log-rank analysi for subtelomeric 1 Ilq allele imbalance status at presentation. none had LOH at DlIS35, and comparing this group with other histologies a trend towards significance was observed for LOH of this marker with non-endometrioid histology (P = 0.04).

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Significant associations do occur between two distant loci while inter- vening loci are excluded from the relationship, as shown for example by D1IS912/Dl1S935 and D1IS935/Dl1S922 (at borderline significance).

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