Inhibition of primordial germ cell proliferation by the medaka male determining gene Dmrt I bY.

While the spatial distribution of pH3 staining was comparable for both, wild type and transgenic embryos, a highly significant (p < 0.001) decrease of 25.5% in the number of replicating cells was observed for the Dmrt1bY:GFP protein expressing embryos (Fig. 4A and 4B ).

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