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The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegans.

J Cell Biol · 2007 · PMC2064129 · PMID 17438072

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may be significantno p-value reported
Alterations in human SM UNC-45 function or concentrations may be significant in hypertrophy, dilation, and failure of the heart, as well as in skeletal muscle wasting in a variety of human disorders.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.