highly significantP < 0.0001
The prevalence odds ratio for the association of K8/K18 mutations with human cirrhosis is 3.8 (95% confidence interval of 2.1–7.1), and the association with liver disease is highly significant when comparing a large American cohort of liver disease patients who underwent liver transplantation with a control group (P < 0.0001; Ku et al., 2005 ).