The deoxyribonucleic acid content of carcinoma of the uterus: an assessment of its possible significance in relation to histopathology and clinical course, based on data from 165 cases.

In contrast, the mean of the upper group (" upper ploidy group ") is close to the normal tetraploid epithelial value (220), the range is somewhat wider, and there are many hypotetraploid cases as well as some in the hexaploid region (mean = 223 ? 43; coefficient of variation = 20 per cent). Although the numbers are fewer, the corpus cases present differences from the cervix cases which may be significant: there are relatively fewer tetraploid tumours and none in the hypertetraploid-hexaploid region; on the other hand, there are ri. 4 ri. q t t4. c c ?2 FIa. 1.-Basic DNA value of 122 untreated cervical carcinomata (above), and 30 untreated corpus carcinomata (below). 2 hypodiploid tumours.

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Table II shows that there are 45 squamous cell tumours in the diploid group and 70 in the higher-than-diploid groups, whereas the 17 tumours of the other two histological types are all above diploid or have no clear mode. This difference is highly significant (p - 0.00054); the limits that we have taken for the "diploid" group are purely arbitrary, but if we narrow the diploid group to 10 per cent or broaden it to ?20 per cent, the differences are still significant (p _ 0.0020 and 0.012 respectively).

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