Serum SHBG levels showed an overall trend to decrease following treatment with the specific anti-oestrogen, falling from a median level of 100 mmol 1-' pretreatment to 55 mmol 1-1 after 8 months of treatment (P= NS.
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Pharmacokinetics, pharmacological and anti-tumour effects of the specific anti-oestrogen ICI 182780 in women with advanced breast cancer.
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