TP53 mutation analyses on breast carcinomas: a study of paraffin-embedded archival material.

A recent study (Bergh et al., 1995) shows that adjuvant therapy, especially with tamoxifen, along with radiotherapy seems to be of less value for breast cancer patients with TP53 mutations and node-positive tumours than patients without mutations. In conclusion our data show that it is possible to use archival material for TP53 mutation analysis and that results are comparable with those obtained from fresh tumour tissue. There was a slight trend towards poorer prognosis in overall and breast cancer corrected survival for patients with TP53 abnormalities.

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We found a highly significant association between the presence of TP53 mutations (CDGE analysis) and TP53 protein accumulation, suggesting that TP53 immunostaining is mainly due to TP53 mutations.

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