TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study.

Compared to controls and using the C/C genotype as a reference, women heterozygous at -509 had an 18% decrease in risk of ER+ breast cancer (OR 0.82, 95% CI 0.67 – 1.00), women homozygous for the T allele had a 38% decrease in risk (OR 0.62, 95% CI 0.42 – 0.90), and there was a highly significant trend in decreased risk across these two genotypes (p = 0.04 for L10P and p = 0.005 for -509).

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Though no overall association was found between L10P and breast cancer risk, a marginally significant an inverse association between the -509 SNP and breast cancer risk was detected (Table 1 ).

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