The 2G allele of promoter region of matrix metalloproteinase-1 as an essential pre-condition for the early onset of oral squamous cell carcinoma.

In fact, it was clarified that the significance of the presence of the MMP-1 2G allele was lower in the subject group 45 years old or older ( p = 0.238, OR = 1.65, 95% CI = 0.75–3.55), and that the impact of the allele was highly significant in the younger group, which was under 45 years old ( p = 0.014, OR = 9.67, 95% CI = 1.20–78.15) (data not shown).

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